Researchers reveal how nanomaterial influences gut microbiome – Gulf News

Study shows extremely thin nanomaterial can influence immune system
Solna, Sweden: The nanomaterial graphene oxide, which is utilised in everything from electronics to biomolecule sensors, can indirectly influence the immune system through the gut microbiome, a new study shows.
Finding of the study conducted on zebrafish by researchers at Karolinska Institutet in Sweden were reported in the journal Nature Nanotechnology.
“This shows that we must factor the gut microbiome into our understanding of how nanomaterials affect the immune system,” said the paper’s corresponding author Bengt Fadeel, professor at the Institute of Environmental Medicine, Karolinska Institutet. “Our results are important for identifying the potential adverse effects of nanomaterial and mitigating or preventing such effects in new materials.”
Graphene is an extremely thin material, a million times thinner than a human hair. It comprises a single layer of carbon atoms and is stronger than steel yet flexible, transparent, and electrically conductive. This makes it extremely useful in a multitude of applications, including in “smart” textiles equipped with wearable electronics and as a component of composite materials, to enhance the strength and conductivity of existing materials.
With the increased use of graphene-based nanomaterials comes a need to examine how these new materials affect the body. Nanomaterials are already known to impact on the immune system, and a few studies in recent years have shown that they can also affect the gut microbiome, the bacteria that naturally occur in the gastrointestinal tract.
The relationship between nanomaterial, gut microbiome and immunity has been the subject of the present study performed using zebrafish. The nanomaterial investigated was graphene oxide, which can be described as a relative of graphene that consists of carbon atoms along with atoms of oxygen. Unlike graphene, graphene oxide is soluble in water and of interest to medical research as, for example, a means of delivering drugs in the body.
In the study, the researchers exposed adult zebrafish to graphene oxide via the water and analysed how it affects the composition of the microbiome. They used both normal fish and fish lacking a receptor molecule in their intestinal cells called the aryl hydrocarbon receptor, commonly abbreviated as AhR, a receptor for various endogenous and bacterial metabolites.
“We were able to show that the composition of the gut microbiome changed when we exposed the fish to graphene oxide, even at a low dose, and that the AhR also affected the gut microbiome,” said the study’s first author Guotao Peng, postdoc researcher at the Institute of Environmental Medicine at Karolinska Institutet.
The researchers have also generated zebrafish larvae that completely lack a natural gut microbiome, which makes it possible to study the effects of individual microbiome components, in this case butyric acid (a fatty acid), which is secreted by certain types of gut bacteria. Butyric acid is known to be able to bind to AhR.
Doing this, the researchers found that the combination of graphene oxide and butyric acid gave rise to so-called type 2 immunity in the fish. The effect turned out to be dependent on the expression of AhR in the intestinal cells.
“This type of immunity is normally seen as a response to parasitic infection. Our interpretation is that the gut immune response can handle graphene oxide in a similar way to how it would handle a parasite,” said Guotao Peng.
Using an advanced method for mapping the immune cells, the researchers were also able to show that a component of the immune system called innate lymphoid cells are found in zebrafish larvae.
“This shows that the zebrafish is a good model for studying the immune system, including the primitive or innate immune system,” said Bengt Fadeel.

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